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PRESTALIA is the first single-pill combination of perindopril and amlodipine medication for the treatment of hypertension
PRESTALIA is a prescription medicine that contains perindopril arginine, an angiotensin converting enzyme inhibitor (ACE inhibitor), and amlodipine, a calcium channel blocker
The drug combination in PRESTALIA shows a greater reduction in blood pressure compared to the individual drugs alone
Lowering blood pressure reduces the risk of cardiovascular events, like stroke or heart attack
The most common adverse events associated with PRESTALIA included peripheral edema, cough, headache, and dizziness; these reactions were generally mild and transient in nature
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What causes high blood pressure?
In many cases, the exact cause of high blood pressure is not known. Factors such as lifestyle, heredity, age, and race may all play a part. For 5% to 10% of patients, their high blood pressure has a specific underlying cause (such as kidney abnormalities, hormonal imbalances, or certain drugs).
ASSOCIATED WITH HIGH BLOOD PRESSURE
There are risk factors associated with high blood pressure. Some risk factors you have no control over; others you can control. When high blood pressure has a specific cause, you can also work to manage that cause, whether it's another medication you're taking or another condition you have.
Risk factors you cannot control
Family: a family history of high blood pressure
Race: high blood pressure affects more than 40% of African Americans
Age: 70% of US adults 65 years or older have high blood pressure Risk factors you CAN control
Drinking too much alcohol
Being overweight or obese
Eating foods that are high in salt or sodium
WARNING: FETAL TOXICITY
When pregnancy is detected, discontinue Prestalia as soon as possible
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus
INDICATIONS AND USAGE
PRESTALIA® (perindopril arginine and amlodipine) is a combination of perindopril, an angiotensin converting enzyme inhibitor, and amlodipine, a dihydropyridine calcium channel blocker, indicated for the treatment of hypertension to lower blood pressure:
In patients not adequately controlled with monotherapy.
As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goals.
Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions
PRESTALIA is contraindicated in patients with hereditary or idiopathic angioedema, with or without previous angiotensin converting enzyme (ACE) inhibitor treatment, and in patients who are hypersensitive to perindopril, to ACE inhibitors, or to amlodipine. Rare cases of angioedema, including intestinal angioedema, have been reported in patients treated with ACE inhibitors. Do not co-administer aliskiren with ACE inhibitors, including PRESTALIA, in patients with diabetes.
Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of PRESTALIA, particularly in patients with severe obstructive coronary artery disease. In patients at risk of excessive hypotension, start PRESTALIA therapy under close medical supervision. Follow patients closely for the first 2 weeks of treatment and whenever the dose of PRESTALIA is increased or a diuretic is added or its dose increased. Monitor renal function periodically in patients treated with PRESTALIA. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function.
The most common adverse events associated with PRESTALIA include peripheral edema, cough, headache, and dizziness.